confers_resistance_to_antibiotic confers_resistance_to_drug_class macrolide antibiotic fluoroquinolone antibiotic erythromycin amikacin gentamicin C aminoglycoside antibiotic cephalosporin ciprofloxacin acriflavine tetracycline tobramycin meropenem resistance-nodulation-cell division (RND) antibiotic efflux pump confers_resistance_to_antibiotic confers_resistance_to_drug_class penicillin beta-lactam chloramphenicol norfloxacin ofloxacin MexXY-OprM antibiotic_resistance MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. MexXY-OprM ARO:3003032