derives_from determinant of antibiotic resistance beta-lactam sensitive penicillin-binding protein beta-lactam resistant penicillin-binding proteins antibiotic_resistance ARO:3003040 Pencillin-binding proteins are transpeptidase proteins essential for cell wall synthesis. PBPs bind to penicillin antibiotics, which inactivates the enzyme and therefore disrupts cell wall synthesis. Multiple mechanisms and determinants are implicated in antibiotic resistant PBP.