confers_resistance_to_antibiotic confers_resistance_to_drug_class derives_from daptomycin confers_resistance_to_antibiotic confers_resistance_to_drug_class peptide antibiotic rifamycin antibiotic daptomycin-resistant beta-subunit of RNA polymerase (rpoB) Daptomycin-resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. ARO:3003090 antibiotic_resistance antibiotic resistant rpoB daptomycin sensitive beta-subunit of RNA polymerase (rpoB)