confers_resistance_to_antibiotic confers_resistance_to_antibiotic isoniazid Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid Mtub_katG_INH Rv1908c katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent. antibiotic_resistance ARO:3003392 isoniazid resistant katG