confers_resistance_to_antibiotic vancomycin teicoplanin confers_resistance_to_antibiotic glycopeptide resistance gene cluster glycopeptide resistance gene cluster VanI vanI_cluster ARO:3003722 This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. antibiotic_resistance