confers_resistance_to_antibiotic fosfomycin confers_resistance_to_antibiotic antibiotic-resistant murA transferase Escherichia coli murA with mutation conferring resistance to fosfomycin antibiotic_resistance ARO:3003775 Ecol_murA_FOF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species.