confers_resistance_to_antibiotic fosfomycin antibiotic resistant gene variant or mutant confers_resistance_to_antibiotic Escherichia coli uhpA with mutation conferring resistance to fosfomycin antibiotic_resistance uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions. Ecol_uhpA_FOF ARO:3003893 UhpA