confers_resistance_to_antibiotic confers_resistance_to_drug_class aminoglycoside antibiotic kanamycin A confers_resistance_to_antibiotic confers_resistance_to_drug_class protein(s) and two-component regulatory system modulating antibiotic efflux kdpDE kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. antibiotic_resistance ARO:3004046