confers_resistance_to_antibiotic confers_resistance_to_antibiotic colistin A colistin B MCR-2.1 MCR-2 ARO:3004110 antibiotic_resistance MCR-2.1 MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016). MCR phosphoethanolamine transferase