confers_resistance_to_antibiotic confers_resistance_to_antibiotic colistin A colistin B MCR-3.1 MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1. antibiotic_resistance MCR-3.1 ARO:3004139 MCR phosphoethanolamine transferase