confers_resistance_to_antibiotic confers_resistance_to_antibiotic para-aminosalicylic acid aminosalicylate resistant dihydrofolate reductase Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid. antibiotic_resistance Mtub_ribD_PAS Rv2671 ARO:3004184