confers_resistance_to_drug_class confers_resistance_to_drug_class antibiotic resistant DNA topoisomerase subunit gyrA triclosan resistant gyrA antibiotic_resistance DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA. ARO:3004333 disinfecting agents and antiseptics