confers_resistance_to_antibiotic confers_resistance_to_antibiotic rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin ARO:3004480 Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. Bado_rpoB_RIF antibiotic_resistance