confers_resistance_to_antibiotic confers_resistance_to_drug_class erythromycin gentamicin C aminoglycoside antibiotic ciprofloxacin spectinomycin streptomycin tobramycin ceftazidime ertapenem piperacillin major facilitator superfamily (MFS) antibiotic efflux pump confers_resistance_to_antibiotic confers_resistance_to_drug_class azithromycin imipenem polymyxin B1 polymyxin B2 polymyxin B3 polymyxin B4 norfloxacin ticarcillin Klebsiella pneumoniae KpnGH-TolC ARO:3004598 Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. antibiotic_resistance