confers_resistance_to_antibiotic confers_resistance_to_antibiotic pyrazinamide Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function. Mtub_rpsA_PZA Rv1630 ARO:3004721 antibiotic_resistance pyrazinamide resistant rpsA