Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics ponA antibiotic_resistance Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. Ngon_PBP1_BLA ARO:3004833