confers_resistance_to_antibiotic levofloxacin confers_resistance_to_antibiotic rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Helicobacter pylori rpoB mutation conferring resistance to rifampicin ARO:3007051 antibiotic_resistance Hpyl_rpoB_RIF Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586.