confers_resistance_to_drug_class confers_resistance_to_drug_class antibiotic inactivation enzyme nitroimidazole antibiotic nitroimidazole reductase ARO:3007103 antibiotic_resistance Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used.