confers_resistance_to_antibiotic confers_resistance_to_antibiotic rifampin rifaximin rifabutin helicase-like RNA polymerase protection protein HelR HelR HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function. antibiotic_resistance ARO:3007208