adjuvants inhibiting antibiotic removal hinokitiol PubChem:3611 ARO:3007612 ChEBI:10447 antibiotic_resistance Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus. CAS:499-44-5 ChEMBL:CHEMBL48310