ionophore with antibiotic activity pyrrolomycin antibiotic Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. antibiotic_resistance ARO:3007615