confers_resistance_to_antibiotic confers_resistance_to_antibiotic isoniazid nalidixic acid norfloxacin ofloxacin sparfloxacin gentamicin metal transporters with antibiotic efflux putative nickel/cobalt transporter ARO:3007659 antibiotic_resistance Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs. NiCoT Rv2856 NicT