adjuvants which alter physiology menadione CAS:58-27-5 Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase. vitamin K3 PubChem:4055 ChEBI:28869 antibiotic_resistance ChEMBL:CHEMBL590 ARO:3007688