polypyridine metallo-beta-lactamase inhibitor nordihydroguaiaretic acid ChEMBL:CHEMBL52 ARO:3007745 Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1. PubChem:4534 antibiotic_resistance ChEBI:7625 CAS:500-38-9