antifungal without defined classification cerulenin antibiotic_resistance ARO:3009177 CAS:17397-89-6 Cerulenin has a role as an antifungal agent, an antiinfective agent, an antilipemic drug, an antimetabolite, a fatty acid synthesis inhibitor and an antimicrobial agent. It functions by inhibiting the biosynthesis of several lipids and sterols by interfering with enzyme function. In fatty acid synthesis, it is reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, it inhibits HMG-CoA synthetase activity. It is a monocarboxylic acid amide and an epoxide and is found naturally in several species including Cephalosporium caerulensfungus, Euglena gracilis, Acremonium, Acrocylindrum and Helicoceras. It is also shown to inhibit feeding and induce dramatic weight loss in mice. ChEMBL:CHEMBL45627 ChEBI:171741 PubChem:5282054