antibiotic target fungal cell wall synthesis enzyme ARO:3009196 Glucosyltransferase enzymes found in fungal organisms which are known targets for antifungal drugs, such as beta-1,3-glucan synthase. Antifungal medications such as echinocandins and caspofungin selectively target and inhibit these enzymes, preventing the formation of vital oligosaccharides and polysaccharides and thereby resulting in cell death. Mutations in these enzymes may prohibit antifungal binding and activity, thus associated with antifungal resistance. antibiotic_resistance