confers_resistance_to_drug_class confers_resistance_to_drug_class triazole antifungal imidazole antibiotic antifungal-resistant cytochrome P450 enzyme azole-resistant fungal cytochrome P450 enzyme antibiotic_resistance The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. ARO:3009200 benzimidazole antifungal