confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic itraconazole azole-resistant fungal cytochrome P450 enzyme Aspergillus fumigatus cyp51a with mutations conferring resistance to itraconazole The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. antibiotic_resistance ARO:3009202 Afum_CYP51a_ITZ antifungal susceptible Cyp51 enzyme