confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic amphotericin B polyene-resistant fungal cytochrome P450 enzyme Aspergillus fumigatus cyp51a with mutations conferring resistance to amphotericin B ARO:3009209 Polyenes like amphotericin B target ergosterol embedded in the fungal cell membrane. Mutations in Cyp51 can affect either the presence of ergosterol, or the structure of ergosterol thereby altering polyene target, and rendering such compounds ineffective. antibiotic_resistance antifungal susceptible Cyp51 enzyme