confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic voriconazole Histoplasma capsulatum Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole antibiotic_resistance ARO:3009223 The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. antifungal susceptible ERG11 lanosterol-14-alpha-demethylase azole resistant fungal 14 alpha demethylase