confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic fluconazole Candida albicans mrr2 with mutations associated with resistance to fluconazole ARO:3009239 The Mrr2 gene encodes a zinc-cluster transcription factor that is specifically associated with the activation of the MDR1 multi-drug efflux transporter. In fungi, mutations in this gene result in overexpression of MDR1 and potential azole resistance. Some evidence also suggests that it may influence the activation of other efflux pumps as well in Candida species. antibiotic_resistance azole-resistant fungal mrr fungal transcription factor