antibiotic resistance gene variant or mutant antifungal-resistant ase1 ARO:3009271 The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. antibiotic_resistance