confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic posaconazole Aspergillus fumigatus ase1 with mutations conferring resistance to posaconazole antibiotic_resistance The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. ARO:3009272 azole-resistant fungal ase1 antifungal susceptible ase1