antibiotic resistance gene variant or mutant antifungal-resistant dhfr antibiotic_resistance ARO:3009284 Dihydrofolate Reductase (DHFR) is an enzyme integral to nucleotide and protein synthesis for eukaryotic life inclusive of fungi. This enzyme is targeted by certain drugs to to halt nucleotide synthesis and killing the target eukaryotic cell. Some of these drugs are useful against fungal infections, but mutations to this gene can lead to resistance against such intervention.