confers_resistance_to_antibiotic confers_resistance_to_antibiotic azole-resistant fungal cytochrome P450 enzyme Colletotrichum truncatum Cyp51 with mutations associated with resistance to flutriafol ARO:3009288 antibiotic_resistance The Cyp51 enzyme belongs to the P450 protein system and is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity inclusive of flutriafol, which is a triazole despite not adhering to traditional azole naming convention. flutriafol