confers_resistance_to_antibiotic confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole atovaquone pyrimethamine antifungal-resistant dhfr Pneumocystis jerovecii dhfr with mutations associated with resistance to Trimethoprim sulfamethoxazole combined with Pyrimethamine atovaquone Dihydrofolate Reductase (DHFR) is an enzyme integral to nucleotide and protein synthesis for eukaryotic life inclusive of fungi. This enzyme is targeted by certain drugs to to halt nucleotide synthesis and killing the target eukaryotic cell. Some of these drugs are useful against fungal infections, but mutations to this gene can lead to resistance against such intervention. antibiotic_resistance ARO:3009290