confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic isavuconazole antifungal susceptible HMG-CoA reductase azole resistant HMG-CoA reductase Aspergillus fumigatus Hmg2 with mutations conferring resistance to isavuconazole antibiotic_resistance ARO:3009367 The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs.