confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic caspofungin Nakaseomyces glabratus Cdc6 with mutations conferring resistance against caspofungin Candida glabrata ARO:3009390 Cdc6 is a gene involved in DNA replication initiation by forming and maintaining the pre-replicative complex and serving as a loading factor for the Mcm proteins onto chromatin. Its combination with a separate, seemingly independent FKS2 mutation results in echinocandin resistance that is more prominent than echinocandin resistance conferred by the FKS2 mutation alone. antibiotic_resistance antifungal susceptible cdc enzyme antifungal resistant cdc