confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic amphotericin B polyene-resistant fungal cytochrome P450 enzyme antifungal susceptible ERG11 lanosterol-14-alpha-demethylase Candida auris ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance against amphotericin B ARO:3009394 The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit polyene activity. antibiotic_resistance Candidozyma auris