confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic tebuconazole azole-resistant fungal cytochrome P450 enzyme antifungal susceptible ERG11 lanosterol-14-alpha-demethylase Zymoseptoria tritici Cyp51 with mutations conferring resistance to tebuconazole ARO:3009403 Mycosphaerella graminicola antibiotic_resistance The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity.