confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic azole-resistant fungal cytochrome P450 enzyme antifungal susceptible Cyp51 enzyme flusilazole Zymoseptoria tritici Cyp51 with mutations conferring resistance to flusilazole ARO:3009409 antibiotic_resistance Mycosphaerella graminicola The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity.