antibiotic molecule fungal succinate dehydrogenase inhibitor ARO:3009539 antibiotic_resistance Succinate dehydrogenase inhibitors (SDHIs) are a class of compounds that inhibit the specified enzyme that is also known as mitochondrial respiratory Complex II. SDH is a unique enzyme because it participates in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC). They have anifungal properties due to their ability to arrest growth, cause cell death, impair sporulation and interfere with hyphal degeneration.