confers_resistance_to_antibiotic derives_from confers_resistance_to_antibiotic azoxystrobin antifungal susceptible Cyp51 enzyme Aspergillus fumigatus Cyp51A with mutations conferring resistance to azoxystrobin ARO:3009545 The cytochrome P450 enzyme Cyp51 is central to fungal ergosterol production. Strobilurin fungicides act on the mitochondrial respiratory chain by binding to the Qo site of cytochrome b, thereby inhibiting electron transport and ATP synthesis. Although strobilurins do not directly target Cyp51, mutations in Cyp51 and other sterol biosynthesis genes can influence overall fungal fitness and occasionally contribute to conferred resistance to other drug classes such as strobilurins. antibiotic_resistance strobilurin resistant fungal cytochrome P450 enzyme