confers_resistance_to_drug_class confers_resistance_to_drug_class antifungal-resistant cytochrome P450 enzyme benzimidazole antifungal benzimidazole resistant fungal cytochrome P450 enzyme The cytochrome P450 enzyme family is central to multiple biosynthetic pathways in fungi, inclusive of sterol synthesis. Benzimidazole fungicides primarily target beta-tubulin to prevent microtubule assembly and cell division. Mutations in certain P450 enzymes have been observed to confer benzimidazole resistance by altering fungal metabolism, cell wall composition, or membrane composition even though P450 enzymes are not the direct drug target. antibiotic_resistance ARO:3009546