confers_resistance_to_drug_class confers_resistance_to_drug_class antifungal-resistant cytochrome P450 enzyme strobilurin fungicide strobilurin resistant fungal cytochrome P450 enzyme ARO:3009547 The cytochrome P450 enzyme family is integral to fungal metabolism inclusive of sterol biosynthesis. Strobilurin fungicides target the Qo site of cytochrome b in the mitochondrial electron transport chain, inhibiting respiration and ATP production. Although strobilurins do not directly target P450 enzymes, mutations in certain fungal P450s can confer strobilurin resistance by altering cellular metabolism, detoxification pathways, or membrane composition. antibiotic_resistance