antifungal-resistant cytochrome P450 enzyme succinate dehydrogenase inhibitor resistant fungal cytochrome P450 enzyme antibiotic_resistance The cytochrome P450 enzyme family is central to several fungal metabolisms, inclusive of sterol biosynthesis. Succinate dehydrogenase inhibitor (SDHI) fungicides target the SDH complex in the mitochondrial electron transport chain, blocking respiration and ATP production. Although SDHIs do not directly target P450 enzymes, mutations or altered expression in certain fungal P450s can affect drug detoxification and cellular metabolism, thereby contributing to conferred resistance. ARO:3009549