antibiotic resistance gene variant or mutant antifungal resistant ATIC enzyme antibiotic_resistance ARO:3009562 ATIC is a bifunctional enzyme that catalyzes the final two steps of the de novo purine biosynthesis pathway in most eukaryotes. Its gene, ADE17, produces a single polypeptide chain that folds into two distinct domains. The first domain isthe 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) Transformylase domain which takes the substrate AICAR and a folate molecule to add a carbon atom. The second is the IMP Cyclohydrolase domain which takes the result of the first reaction and transforms it into a ring to create Inosine Monophosphate (IMP), which is the precursor to all DNA/RNA bases. AICAR transformylase refers to the specific functional domain of the ADE17 enzyme that is targeted or inhibited by certain chemical compounds.