confers_resistance_to_drug_class confers_resistance_to_drug_class antibiotic without defined classification gene conferring resistance via absence fungal BycA Transcribed BycA is a protein that influences the morphological state of fungi by unrestricting Protein Kinase A (PKA). Under normal conditions calcineurin acts as the master regulator by suppressing the transcription of the bycA gene at the mRNA level. By keeping BycA levels minimized, downstream PKA activity remains low which ultimately permits virulent hyphal growth in fungi. When calcineurin is inhibited the transcriptional suppression on the bycA promoter is immediately lifted. This ultimately causes the fungal cell to bind extracellular amino acids leading to a conformational change that forces the fungus into a yeast-locked, avirulent state. antibiotic_resistance ARO:3009565