confers_resistance_to_drug_class antibiotic resistance gene variant or mutant confers_resistance_to_drug_class nucleoside antibiotic antifungal resistant Ura URA enzymes in fungi catalyze sequential steps in the de novo pyrimidine biosynthesis pathway, converting simple precursors ultimately into UMP and UDP for nucleotide synthesis. Their relevance to antifungal resistance lies in their intersection with 5-flucytosine metabolism where the compound is converted intracellularly into toxic fluorinated pyrimidine analogs that hijack the pathway. ARO:3009632 antibiotic_resistance