ribosomally synthesized and post-translationally modified peptide antibiotics lasso peptide antibiotics ARO:3009658 Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) characterized by a threaded lariat-like structure, in which the C-terminal peptide tail is trapped within an N-terminal macrolactam ring. This unique topology contributes to their exceptional stability and diverse biological activities. Many lasso peptides exhibit antibacterial activity by targeting essential cellular processes, including transcription and proteolysis, although their molecular targets are highly diverse. antibiotic_resistance